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Blood viscosity and you can blood circulation pressure: character away from temperatures and you can hyperglycemia

Yildirim Cinar, A good. Mete Senyol, Kamber Duman, Blood viscosity and you can hypertension: part regarding heat and you may hyperglycemia, American Log from Blood circulation pressure, Regularity step step 14, Point 5, , Users 433–438,


We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The goal of all of our study would be to check out the relationship certainly one of heat, sugar quantity, and you will viscosity of bloodstream and you will plasma, also to assess its effects toward blood circulation pressure (BP) considering Hagen-Poiseuille’s hydrodynamics equation.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F1 ? F2) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F1 ? F2), where ? is the viscosity of the fluid, F1 and F2 are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Bloodstream viscosity and you can blood pressure levels: role out of heat and you will hyperglycemia

It has been revealed one ranging from % and you will % values off hematocrit, all eleven% increase https://datingranking.net/local-hookup/minneapolis/ in hematocrit expands bloodstream viscosity by 20%. Inside state, according to Poiseuille’s equation, flow speed decreases from the %, which may cause tissues ischemia. To store new circulatory program inside the equilibrium (that is, staying the fresh disperse price adequate and you can stopping structure ischemia), a 20% increase in BP otherwise cuatro.66% vasodilation is needed. step 3 not, the human circulatory method is perhaps not an exact finalized system, because blood viscosity is going to be altered to the assimilation out of dinner otherwise medicines. 4–8 While doing so, the effects of fat molecules and of particular drugs for the bloodstream viscosity and you may hemodynamics including BP had been reported. As atherosclerotic ships dont dilate well enough given that a reaction to vasodilator drugs, it’s been advised one to improved bloodstream viscosity are only able to become settled with a beneficial BP escalation in including circumstances. 9–twelve Along with, the new relationships certainly one of BP, headache, coagulation, flow speed, and you will bloodstream viscosity were demonstrated via the beliefs of hemodynamics. 13, 14

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